NeuroScopic
Dr. Sepulveda 140, Int 2 64710 Monterrey, Nuevo León, México

Para cerrar con el tema de ayer. También les recomiendo al gran William James. Equilibrado fin de semana. In order to form for one's self a just notion of the operations which result in the production of thought, it is necessary to conceive of the brain as a peculiar organ, specially designed for the production thereof, just as the stomach is designed to effect digestion, the liver to filter the bile, the parotids and the maxillary and sublingual glands to prepare the salivary juices. Pierre-Jean-Georges Cabanis Rapports du Physique et du Moral de l'Homme (1805)

Estamos a pocos días de dar inicio al Curso de "Formación Didáctica en Neurofeedback" que se llevará a cabo de forma virtual. Puedes consultar el temario completo en: https://smbn.org.mx/cursonfb/... Inscripciones a través del sitio web smbn.org.mx ¡No te lo pierdas! #Neurociencia #SMBN #FYI #neuroscopic

Efectos sexo-específicos en procesos epigenéticos en memoria y aprendizaje de miedo e hipersensibilidad al dolor. En ratones... Sex-specific effects of the histone variant H2A.Z on fear memory, stress-enhanced fear learning and hypersensitivity to pain Emerging evidence suggests that histone variants are novel epigenetic regulators of memory, whereby histone H2A.Z suppresses fear memory. However, it is not clear if altered fear memory can also modify risk for PTSD, and whethe...r these effects differ in males and females. Using conditional-inducible H2A.Z knockout (cKO) mice, we showed that H2A.Z binding is higher in females and that H2A.Z cKO enhanced fear memory only in males. However, H2A.Z cKO improved memory on the non-aversive object-in-place task in both sexes, suggesting that H2A.Z suppresses non-stressful memory irrespective of sex. Given that risk for fear-related disorders, such as PTSD, is biased toward females, we examined whether H2A.Z cKO also has sex-specific effects on fear sensitization in the stress-enhanced fear learning (SEFL) model of PTSD, as well as associated changes in pain sensitivity. We found that H2A.Z cKO reduced stress-induced sensitization of fear learning and pain responses preferentially in female mice, indicating that the effects of H2A.Z depend on sex and the type of task, and are influenced by history of stress. These data suggest that H2A.Z may be a sex-specific epigenetic risk factor for PTSD susceptibility, with implications for developing sex-specific therapeutic interventions. https://www.nature.com/articles/s41598-020-71229-x

https://www.nature.com/articles/d41586-020-01266-z

Nos sintonizamos este jueves, en #CEREBRALMENTE, con el Dr. Novo en vivo, para hablar del muy controvertido tema de los "Antidepresivos". ¡No se lo pierdan! #neurociencia #FYI #Neuroscopic

No se pierdan este jueves, en #CEREBRALMENTE, al Dr. Novo platicando acerca de un tema muy prostituido: La Biologia cuántica. ¡Nos vemos el jueves a las 2 p.m.!... #neurociencia #FYI #Neuroscopic #biologiacuantica

¡De vuelta a los inicios! No se pierdan este jueves, la emisión en vivo de #CEREBRALMENTE con el Dr. Novo, para hablar de las bases de la neurociencia y el cerebro. ¡Los esperamos! #neuroscopic #neurociencia #FYI #backtobasics

No todas las máscaras son iguales

En este día de los abuelos. La prevención de trastornos demenciales, especialmente la Enfermedad de Alzheimer, es de los retos más importantes de nuestra generación; afortunadamente se ha logrado disminuir la incidencia en los últimos 20 años aplicando medidas simples y baratas en grandes poblaciones. Este es un articulo muy reciente sobre los factores de riesgo y factores protectivos más importantes. NO hay mucha novedad desde hace ya varias décadas. Evidence-based preventio...n of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. A total of 44 676 reports were identified, and 243 OPSs and 153 RCTs were eligible for analysis after exclusion based on pre-decided criteria, from which 104 modifiable factors and 11 interventions were included in the meta-analyses. Twenty-one suggestions are proposed based on the consolidated evidence, with Class I suggestions targeting 19 factors: 10 with Level A strong evidence (education, cognitive activity, high body mass index in latelife, hyperhomocysteinaemia, depression, stress, diabetes, head trauma, hypertension in midlife and orthostatic hypotension) and 9 with Level B weaker evidence (obesity in midlife, weight loss in late life, physical exercise, smoking, sleep, cerebrovascular disease, frailty, atrial fibrillation and vitamin C). In contrast, two interventions are not recommended: oestrogen replacement therapy (Level A2) and acetylcholinesterase inhibitors (Level B). https://jnnp.bmj.com/conte/early/2020//01/jnnp-2019-321913 See more